Phosphorlyted B vitamins
Why phosphorylated? There is not much literature on the increased efficacy of having the phosphate group already added to the B vitamins, though clinicians working with the very sick become acutely aware of the added advantage and the inherent safety of having supplemental coenzymes energetically preloaded.
ATP - The Loading Mechanism - Basic biology teaches that the basic function of the Krebs (citric acid) Cycle and the electron transport chain is to make ATP, adenosine triphosphate, the universal energy packets of the living system. Respiration adds a third phosphate group to make it a triphosphate. (In aerobic respiration with oxygen we get 38 ATP per glucose molecule burned but only 2 in anaerobic respiration.) ATP donates one of its phosphorous to an enzyme, or muscle group, etc. Whenever energy is needed for the life process, it is powered by the electrochemical gradient release from the attached phosphate group. Phosphorylated B vitamins are coenzymes that are stable and energy-preloaded for immediate action.
We need less phosphorylated enzymes to accomplish the desired results. Biotics Research's focus on bioactivity lead to providing the phosphorylated B vitamins. Since many biochemical steps and several ATP are required for the conversion, we can count on the phosphorylated enzymes always working if there is not enough ATP energy available to convert a synthetic or inactive stored enzyme to the active form.
Being Safe. Vitamin B6 in its physiologically active coenzyme form of pyridoxal 5' phosphate (P5P) is involved in amino acid, nucleic acid, glycogen, porphyrin and lipid metabolism. It thus affects hormone modulation, erythrocyte, and immune and nervous system functions. A strong example of especially needing the phosphorylated form is when supplementing patients with severe cirrhosis, with up to 90% suffering from B6 deficiency. If high levels of the commercially available pyridoxine HCl are given to a patient with cirrhosis, the impaired liver does not convert it to the phosphorylated form rapidly enough. The increased circulating pyridoxine HCl is directly neurotoxic. (Sensory neuropathy with low-dose pyridoxine. Parry GL, Bredesen DE, Neurology35:1466-1468; 1985.) Oral P5P will modulate this. (Protective effect of pyridoxal-5'-phosphate against tobramycin nephrotoxicity. Jap J Pharmacol 52:11-21; 1990.)
Awareness of B6/B12 History. Karl Folkers isolated and identified B6 and B12. He crystallized B6 in 1939 and determined the commercial synthesis of B6, and gave insightful observations that nearly 95% of the population is deficient to some degree in vitamin B6. He noted that B6 acts as a coenzyme for more than 50 apoenzymes (an inactive form of enzyme needing a coenzyme), and that clinical studies suggest that B6 deficiency could play a role in diverse human medical disorders. His work on the use of B12 revolutionized the raising of livestock and poultry. B12 became the major product of animal husbandry. (He is also famous for work on Q10. 70% of patients with congestive heart failure in Japan benefit. He appreciates our emulsified Co Q10.) (Karl Folkers Wins ACS's Highest Award in Chemistry. Baum, Rudy M.; C&EN San Francisco, June 17 1985.) Biotics Research through insight gained from his intensive work and their own, produces many of the quality products ahead of the curve in these areas.
Natural foods assay for low amounts of P5P. It is converted from the stored inactive forms of mainly pyridoxine in vegetables and pyridoxamine and pyridoxal in animals, and only as needed. (Conversion of vitamin B6 to active forms in the red blood cell. Anderson, B.B. et al. J. Clin Invest 50:1901-1909; 1971.) Looking at total B6 active and inactive - liver, with one of the highest levels, contains only 0.73 mg of B6 per 100 g of liver. Plant levels are even less. (Vegetarians are vulnerable to B deficiency.) (Dietary vitamin B6 intake and food sources in the US population. Kant A.K. & Block G.:NHANES II, 1976-1980). For supplements to provide the needed levels, units must be added, especially for the phosphorylated units.
Consider the following phosphorylated supplements:
Bio-B 100 - a phosphorylated multiple vitamin B complex (activity is not limited by conversion capability)
Bio-3B-G - B1, 2 & 6 for vasoconstricting properties, adrenal cortical hypofunction, severe fatigue, etc
Bio-GGG-B - more riboflavin for vasodilating properties, hypertension, muscle spasms, edema, etc
B6 Phosphate (P5P)-with carpal tunnel, joint pain, trigger finger, homocystinuria, low liver transaminases,
BioImmunozyme Forte, BioCardiozyme Forte, BioCardio Paks and BioGlycozyme Forte
- all phosphorylated into formulations for conditions requiring self-contained energy release coenzymes.
NutriClear - meal-replacement powder to support and heal a compromised system, beginning with the gut.
Dietary Sources of B6 include: most meats, then edible seeds and nuts, vegetables and fruits.